The emerging role of epigenetic therapeutics in immuno-oncology
MJ Topper, M Vaz, KA Marrone, JR Brahmer… - Nature Reviews …, 2020 - nature.com
The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …
treatment, revolutionizing the management of many types of cancer. Despite the promise of …
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application
C Hu, X Liu, Y Zeng, J Liu, F Wu - Clinical Epigenetics, 2021 - Springer
DNA methylation, an epigenetic modification, regulates gene transcription and maintains
genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at …
genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at …
[HTML][HTML] Transcriptional regulation and its misregulation in disease
TI Lee, RA Young - Cell, 2013 - cell.com
The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …
Dynamic DNA methylation across diverse human cell lines and tissues
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …
a complex relationship with gene expression, plays an important role in defining cell types …
Epigenetics and colorectal cancer
VV Lao, WM Grady - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …
Epigenetic determinants of cancer
Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study
Q Shen, J Fan, XR Yang, Y Tan, W Zhao, Y Xu… - The lancet …, 2012 - thelancet.com
Background Hepatocellular carcinoma (HCC) is prevalent worldwide and improvements in
timely and effective diagnosis are needed. We assessed whether measurement of Dickkopf …
timely and effective diagnosis are needed. We assessed whether measurement of Dickkopf …
[HTML][HTML] Infrared spectroscopy and microscopy in cancer research and diagnosis
G Bellisola, C Sorio - American journal of cancer research, 2012 - ncbi.nlm.nih.gov
Since the middle of 20 th century infrared (IR) spectroscopy coupled to microscopy (IR
microspectroscopy) has been recognized as a non destructive, label free, highly sensitive …
microspectroscopy) has been recognized as a non destructive, label free, highly sensitive …
Cancer epigenetics: an introduction
Epigenetic and genetic alterations contribute to cancer initiation and progression.
Epigenetics refers to the study of heritable changes in gene expression without alterations in …
Epigenetics refers to the study of heritable changes in gene expression without alterations in …