Increasing contamination of the environment by toxic compounds such as endocrine
disrupting chemicals (EDCs) is one of the major causes of reproductive defects in both …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Extensive human epidemiologic and animal model data indicate that during critical periods
of prenatal and postnatal mammalian development, nutrition and other environmental stimuli …

Environmental constraints during early life result in phenotypic changes that can be
associated with increased disease risk in later life. This suggests persistent alteration of …

DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …

Oxidative damage to DNA appears to be a factor in cancer, yet explanations for why highly
elevated levels of such lesions do not always result in cancer remain elusive. Much of the …

Transdifferentiation is a process whereby one cell type committed to and progressing along
a specific developmental lineage switches into another cell type of a different lineage …

The term epigenetic modification denotes reversible traits of gene expression that do not
include alterations to the DNA sequence. These epigenetic alterations are responsible for …

Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …

The RUNX are key regulators of lineage-specific gene expression in major developmental
pathways. The expression of RUNX genes is tightly regulated, leading to a highly specific …