Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common,
potentially lethal, monogenic diseases and is caused predominantly by mutations in …

Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death worldwide. Besides the lymphatic and haematogenous routes …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations to PKD1 or
PKD2, triggering progressive cystogenesis and typically leading to end-stage renal disease …

Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …

Polycystic kidney disease (ADPKD) results from failure of the kidney to properly maintain
three-dimensional structure after loss of either polycystin-1 or-2. Mice with kidney selective …

Polycystin-1, which is encoded by a gene that is mutated in autosomal dominant polycystic
kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling …

We examined the osteoblast/osteocyte expression and function of polycystin-1 (PC1), a
transmembrane protein that is a component of the polycystin-2 (PC2)-ciliary mechano …

The most severe form of autosomal dominant polycystic kidney disease occurs in patients
with mutations in the gene (PKD1) encoding polycystin-1 (PC1). PC1 is a complex polytopic …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially
lethal monogenic disorder, with more than 12 million cases worldwide. The two causative …

In polycystic kidney disease (PKD), intracellular cAMP promotes cyst enlargement by
stimulating mural epithelial cell proliferation and transepithelial fluid secretion. The …