Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …
Epigenetic modifications in stress response genes associated with childhood trauma
Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
Physical exercise as an epigenetic modulator of brain plasticity and cognition
J Fernandes, RM Arida, F Gomez-Pinilla - Neuroscience & Biobehavioral …, 2017 - Elsevier
A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …
function, the effects of which can last for considerable time. An emerging line of scientific …
[HTML][HTML] Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
S Cortellino, J Xu, M Sannai, R Moore, E Caretti… - Cell, 2011 - cell.com
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
JG Herman, JR Graff, S Myöhänen… - Proceedings of the …, 1996 - National Acad Sciences
Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …
understanding diverse biological processes such as the regulation of imprinted genes, X …
Cancer epigenomics: beyond genomics
J Sandoval, M Esteller - Current opinion in genetics & development, 2012 - Elsevier
For many years cancer research has focused on genetic defects, but during the last decade
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …
Positional cloning of the mouse circadian clock gene
DP King, Y Zhao, AM Sangoram, LD Wilsbacher… - Cell, 1997 - cell.com
We used positional cloning to identify the circadian Clock gene in mice. Clock is a large
transcription unit with 24 exons spanning∼ 100,000 bp of DNA from which transcript classes …
transcription unit with 24 exons spanning∼ 100,000 bp of DNA from which transcript classes …
[图书][B] Hayes' principles and methods of toxicology
AW Hayes, T Kobets - 2023 - taylorfrancis.com
Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …
informative reference for the concepts, methodologies, and assessments integral to …
[图书][B] Epigenetic inheritance and evolution: the Lamarckian dimension
E Jablonka, MJ Lamb - 1995 - books.google.com
Does the inheritance of acquired characteristics play a significant role in evolution? In this
book, Eva Jablonka and Marion J. Lamb attempt to answer that question with an original …
book, Eva Jablonka and Marion J. Lamb attempt to answer that question with an original …