Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …

A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …

DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …

Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …

For many years cancer research has focused on genetic defects, but during the last decade
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …

We used positional cloning to identify the circadian Clock gene in mice. Clock is a large
transcription unit with 24 exons spanning∼ 100,000 bp of DNA from which transcript classes …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Does the inheritance of acquired characteristics play a significant role in evolution? In this
book, Eva Jablonka and Marion J. Lamb attempt to answer that question with an original …