Renal cell carcinoma (RCC) is a commonly diagnosed and histologically diverse urologic
malignancy. Clear cell RCC (ccRCC) is by far the most common, followed by the papillary …

Renal cell carcinoma (RCC) comprises a group of malignancies arising from the kidney with
unique tumour-specific antigen (TSA) signatures that can trigger cytotoxic immunity. Two …

Recent insights into the role of the von-Hippel Lindau (VHL) tumor suppressor gene in
hereditary and sporadic clear-cell renal cell carcinoma (ccRCC) have led to new treatments …

Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital
polycythemia, and are found in many sporadic tumor types as well. Reports of VHL …

Primary renal neoplasms are uncommon in domestic animals; they are usually malignant in
dogs, cats, and horses and benign in cattle. Nephroblastoma also has a unique origin in the …

Renal cell carcinoma is the most lethal of the common urologic malignancies, with no
available effective therapeutics. Tetrac (tetraiodothyroacetic acid) is a deaminated analogue …

Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the
kidney, and is characterized histologically by large intracellular lipid deposits. These …

To evaluate the mechanisms and consequences of chromosomal aberrations in colorectal
cancer (CRC), we used a combination of spectral karyotyping, array comparative genomic …

Pseudohypoxia plays a central role in the progression and therapeutic resistance of clear
cell renal cell carcinoma (ccRCC); however, the underlying mechanisms are poorly …

Improvements in our understanding of the genetic basis of human disease and increased
utilization of genetic testing have identified a variety of heritable disorders associated with …