Nonalcoholic fatty liver disease (NAFLD) is a worldwide rising challenge because of hepatic,
but also extrahepatic, complications. Thyroid hormones are master regulators of energy and …

Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …

Single-cell chromatin accessibility sequencing (scATAC-seq) reconstructs developmental
trajectory by phenotypic similarity. However, inferring the exact developmental trajectory is …

Spatiotemporal regulation of cell type-specific gene expression is essential to convert a
zygote into a complex organism that contains hundreds of distinct cell types. A class of cis …

Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …

Traditionally, it has been believed that inheritance is driven as phenotypic variations
resulting from changes in DNA sequence. However, this paradigm has been challenged and …

DNA methylation (5mC) is a repressive gene regulatory mark widespread in vertebrate
genomes, yet the developmental dynamics in which 5mC patterns are established vary …

Simple Summary Accurate timing of photoperiod changes is vital for animal reproduction.
Previous research has shown that the polymorphisms and expression of melatonin receptor …

Summary Long interspersed element 1 (L1) retrotransposons are implicated in human
disease and evolution. Their global activity is repressed by DNA methylation, but …

Abstract Background and Aims Anti-tumour necrosis factor [TNF] treatment failure in patients
with inflammatory bowel disease [IBD] is common and frequently related to low drug …