The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …

Osteonecrosis is a common orthopedic disease in clinic, resulting in joint collapse if no
appropriate treatment is performed in time. Core decompression is a general treatment …

Brain microvascular endothelial cells (BMECs) are an essential component of the blood-
brain barrier (BBB) that shields the brain against toxins and immune cells. While BBB …

The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …

Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation and
reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Because …

Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to
PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four
epoxyeicosatrienoic acid (EET) regioisomers, 5, 6-, 8, 9-, 11, 12-, and 14, 15-EET, that …

Epidemiological and preclinical evidence supports that omega-3 dietary fatty acids (fish oil)
reduce the risks of macular degeneration and cancers, but the mechanisms by which these …