Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …

Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …

Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …

Environmental toxicants can alter epigenetic regulatory features such as DNA methylation
and microRNA expression. As the sensitivity of epigenomic regulatory features may be …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

Gestational age (GA) and birth weight have been implicated in the determination of long-
term health. It has been hypothesized that changes in DNA methylation may mediate these …

Background: Hypertension is common in older individuals and is a major risk factor for
cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of …

Due to its convenience, the blood is commonly used in epigenomic studies, but its
heterogeneous nature leads to interpretation difficulties, given the now widely recognized …