The prognostic value of MGMT promoter methylation in glioblastoma: a meta‐analysis of clinical trials
MM Binabaj, A Bahrami, S ShahidSales… - Journal of cellular …, 2018 - Wiley Online Library
The DNA repair protein O6‐Methylguanine‐DNA methyltransferase (MGMT) is suggested to
be associated with resistance to alkylating agents such as Temozolomide which is being …
be associated with resistance to alkylating agents such as Temozolomide which is being …
Principles and challenges of genome-wide DNA methylation analysis
PW Laird - Nature Reviews Genetics, 2010 - nature.com
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …
eukaryotes that has important implications for normal biology and disease. Therefore …
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
H Noushmehr, DJ Weisenberger, K Diefes, HS Phillips… - Cancer cell, 2010 - cell.com
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
DNA methylation is the most studied epigenetic mark and CpG methylation is central to
many biological processes and human diseases. Since cancer has highlighted the …
many biological processes and human diseases. Since cancer has highlighted the …
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer
M Sauvageau, G Sauvageau - Cell stem cell, 2010 - cell.com
Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify
chromatin and participate in the establishment and maintenance of cell fates. These proteins …
chromatin and participate in the establishment and maintenance of cell fates. These proteins …
Cancer epigenomics: beyond genomics
J Sandoval, M Esteller - Current opinion in genetics & development, 2012 - Elsevier
For many years cancer research has focused on genetic defects, but during the last decade
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
M Weller, R Stupp, G Reifenberger… - Nature Reviews …, 2010 - nature.com
The DNA repair enzyme O 6-methylguanine-DNA methyltransferase (MGMT) antagonizes
the genotoxic effects of alkylating agents. MGMT promoter methylation is the key mechanism …
the genotoxic effects of alkylating agents. MGMT promoter methylation is the key mechanism …
Caveolae: Formation, dynamics, and function
Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a
platform generated by caveolin integral membrane proteins and membrane lipids. This …
platform generated by caveolin integral membrane proteins and membrane lipids. This …
The emerging role of GATA transcription factors in development and disease
MHFM Lentjes, HEC Niessen, Y Akiyama… - Expert reviews in …, 2016 - cambridge.org
The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …
Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies
RG Urdinguio, JV Sanchez-Mut, M Esteller - The Lancet Neurology, 2009 - thelancet.com
Epigenetic mechanisms such as DNA methylation and modifications to histone proteins
regulate high-order DNA structure and gene expression. Aberrant epigenetic mechanisms …
regulate high-order DNA structure and gene expression. Aberrant epigenetic mechanisms …