Loss or rearrangement of genetic information can result from incorrect responses to DNA
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …

The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction
in schizophrenia are the main issues attracting the attention of psychiatrists over the last …

Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …

The epigenome and three-dimensional (3D) genomic architecture are emerging as key
factors in the dynamic regulation of different transcriptional programs required for neuronal …

INTRODUCTION Chromosomal conformations, topologically associated chromatin domains
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …

Neuronal-activity-dependent transcription couples sensory experience to adaptive
responses of the brain including learning and memory. Mechanisms of activity-dependent …

Adolescent alcohol drinking is known to contribute to the development and severity of
alcohol use disorders (AUDs) later in adulthood. Recent studies have shown that long non …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …

Large-scale consortia mapping the genomic risk architectures of schizophrenia provide vast
amounts of molecular information, with largely unexplored therapeutic potential. We …

The Kaposi's sarcoma-associated herpesvirus (KSHV) genome consists of an approximately
140-kb unique coding region flanked by 30–40 copies of a 0.8-kb terminal repeat (TR) …