The aorta is the largest elastic artery in the human body and is classically divided into two
anatomical segments, the thoracic and the abdominal aorta, separated by the diaphragm …

Mitochondria are the energy supply sites of cells and are crucial for eukaryotic life.
Mitochondrial dysfunction is involved in the pathogenesis of abdominal aortic aneurysm …

Background Idiopathic pulmonary fibrosis is a chronic progressive, lethal disease in which
ectopic lung fibroblast (LF) activation plays a vital part. We have previously shown that …

A link between increased glycolysis and vascular calcification has recently been reported,
but it remains unclear how increased glycolysis contributes to vascular calcification. We …

Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of abdominal aortic
aneurysm (AAA), located in adventitia and intraluminal thrombus. We compared the …

The antibiotic doxycycline is known to inhibit inflammation and was therefore considered as
a therapeutic to prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial …

Background Abdominal aortic aneurysm (AAA), characterized by a continued expansion of
the aorta, leads to rupture if not surgically repaired. Mice aid the study of disease …

Background: The molecular mechanisms associated with thoracic aortic dissection (TAD)
remain poorly understood. A comprehensive high-throughput sequencing-based analysis of …

The long noncoding RNA (lncRNA) CARMN (cardiac mesoderm enhancer associated
noncoding RNA) is a highly conserved lncRNA that expresses primarily by smooth muscle …

Neutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial
proteins, are released by neutrophils in response to pathogens but are also recognized for …