NAFLD affects a large proportion of the US population and its incidence and prevalence are
increasing to epidemic proportions around the world. As with other liver diseases that cause …

Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing
damaged materials and mobilizing energy reserves in conditions of starvation. Although …

Mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are in a
high-flux metabolic state, with a high dependence on threonine catabolism. However, little is …

Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Cancer is one of the most significant diseases associated with chronic alcohol consumption,
and chronic drinking is a strong risk factor for cancer, particularly of the upper aerodigestive …

Simple Summary Epigenetic mechanisms including methylation play an essential role in
regulating gene expression not only in cancer cells but also in immune cells. Although role …

Stilbene is an abundant structural scaffold in nature, and stilbene‐based compounds have
been widely reported for their biological activity. Notably,(E)‐resveratrol and its natural …

Betaine-homocysteine S-methyltransferase (BHMT) uses betaine to catalyze the conversion
of homocysteine (Hcy) to methionine. There are common genetic polymorphisms in the …

Methionine metabolism plays a central role in methylation reactions, production of
glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by …