[HTML][HTML] A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …
diseases. The epigenome differs between cell types and has until now only been …
[HTML][HTML] BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions
DNA methylation is an important epigenetic modification involved in gene regulation, which
can now be measured using whole-genome bisulfite sequencing. However, cost, complexity …
can now be measured using whole-genome bisulfite sequencing. However, cost, complexity …
The NIH roadmap epigenomics mapping consortium
BE Bernstein, JA Stamatoyannopoulos… - Nature …, 2010 - nature.com
The NIH Roadmap Epigenomics Mapping Consortium | Nature Biotechnology Skip to main
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content Thank you for visiting nature.com. You are using a browser version with limited support …
[HTML][HTML] Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
H Noushmehr, DJ Weisenberger, K Diefes, HS Phillips… - Cancer cell, 2010 - cell.com
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …
Circos: an information aesthetic for comparative genomics
M Krzywinski, J Schein, I Birol, J Connors… - Genome …, 2009 - genome.cshlp.org
We created a visualization tool called Circos to facilitate the identification and analysis of
similarities and differences arising from comparisons of genomes. Our tool is effective in …
similarities and differences arising from comparisons of genomes. Our tool is effective in …
Epigenetics in cancer
Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …
Conserved role of intragenic DNA methylation in regulating alternative promoters
AK Maunakea, RP Nagarajan, M Bilenky, TJ Ballinger… - Nature, 2010 - nature.com
Although it is known that the methylation of DNA in 5′ promoters suppresses gene
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …
A Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data
DNA methylation is an important epigenetic modification that has essential roles in cellular
processes including gene regulation, development and disease and is widely dysregulated …
processes including gene regulation, development and disease and is widely dysregulated …
Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies
Background During the past 5 years, high-throughput technologies have been successfully
used by epidemiology studies, but almost all have focused on sequence variation through …
used by epidemiology studies, but almost all have focused on sequence variation through …
Principles and challenges of genome-wide DNA methylation analysis
PW Laird - Nature Reviews Genetics, 2010 - nature.com
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …
eukaryotes that has important implications for normal biology and disease. Therefore …