Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Differentiation-related DNA methylation is receiving increasing attention, partly owing to
new, whole-genome analyses. These revealed that cell type-specific differential methylation …

A number of human diseases, such as arthritis and atherosclerosis, include characteristic
pathology in specific anatomical locations. Here we show transcriptomic differences in …

Hox genes are an evolutionary highly conserved gene family. They determine the anterior-
posterior body axis in bilateral organisms and influence the developmental fate of cells …

Skeletal muscle comprises a family of diverse tissues with highly specialized functions.
Many acquired diseases, including HIV and COPD, affect specific muscles while sparing …

Muscle fibers are syncytial postmitotic cells that can acquire exogenous nuclei from resident
muscle stem cells, called satellite cells. Myonuclei are added to muscle fibers by satellite …

Objectives To elucidate the functional epigenomic landscape of articular cartilage in
osteoarthritis (OA) affected knee and hip joints in relation to gene expression. Methods …

In spite of substantial advances in defining the immunobiology and function of structural
cells in lung diseases there is still insufficient knowledge to develop fundamentally new …

Differentially methylated or hydroxymethylated regions (DMRs) in mammalian DNA are often
associated with tissue-specific gene expression but the functional relationships are still …

Folic acid, a water soluble B vitamin, plays an important role in cellular metabolic activities,
such as functioning as a cofactor in one‐carbon metabolism for DNA and RNA synthesis as …