One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease. The natural history of DKD includes glomerular hyperfiltration …

Control of DNA methylation level is critical for gene regulation, and the factors that govern
hypomethylation at CpG islands (CGIs) are still being uncovered. Here, we provide evidence …

Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …

Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …

The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

The pluripotent ground state is defined as a basal state free of epigenetic restrictions, which
influence lineage specification. While naive embryonic stem cells (ESCs) can be maintained …

In vertebrates, cytosine-guanine (CpG) dinucleotides are predominantly methylated, with∼
80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with …

Enhancers control the establishment of spatiotemporal gene expression patterns throughout
development. Over the past decade, the development of new technologies has improved our …

DNA methylation is an essential part of the epigenome chromatin modification network,
which also comprises several covalent histone protein post-translational modifications. All …