Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

In the modern world, cardiovascular disease is a leading cause of death for both men and
women. Epidemiologic studies consistently have suggested an association between low …

Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

Motivation: Recently there has been increasing interest in the effects of cell mixture on the
measurement of DNA methylation, specifically the extent to which small perturbations in cell …

Background Recent interest in reference-free deconvolution of DNA methylation data has
led to several supervised methods, but these methods do not easily permit the interpretation …

Exposure to early life stress (ELS), such as childhood abuse and neglect is a well
established major risk factor for developing psychiatric and behavioral disorders later in life …

Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also
over larger genomic regions. In most human tissues, the vast majority of the genome is …

Background: Fetal Growth Restriction (FGR) is one of the most common noxious antenatal
conditions in humans, inducing a substantial proportion of preterm delivery and leading to a …

Detection of plasma circulating nucleic acids (CNAs) requires the use of extremely sensitive
and precise methods. The commonly used quantitative real-time polymerase chain reaction …

The placenta is a transient organ found in eutherian mammals that evolved primarily to
provide nutrients for the developing fetus. The placenta exchanges a wide array of nutrients …