Advances in the profiling of DNA modifications: cytosine methylation and beyond
Chemical modifications of DNA have been recognized as key epigenetic mechanisms for
maintenance of the cellular state and memory. Such DNA modifications include canonical 5 …
maintenance of the cellular state and memory. Such DNA modifications include canonical 5 …
Epigenetic control of gene regulation during development and disease: A view from the retina
Complex biological processes, such as organogenesis and homeostasis, are stringently
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …
Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation
Background DNA methylation plays an important role in regulating gene expression during
many biological processes. However, the mechanism of DNA-methylation-dependent gene …
many biological processes. However, the mechanism of DNA-methylation-dependent gene …
Epigenomic landscapes of retinal rods and cones
Rod and cone photoreceptors are highly similar in many respects but they have important
functional and molecular differences. Here, we investigate genome-wide patterns of DNA …
functional and molecular differences. Here, we investigate genome-wide patterns of DNA …
Cell-free DNA-methylation-based methods and applications in oncology
F Galardi, F De Luca, D Romagnoli, C Biagioni… - Biomolecules, 2020 - mdpi.com
Liquid biopsy based on cell-free DNA (cfDNA) enables non-invasive dynamic assessment of
disease status in patients with cancer, both in the early and advanced settings. The analysis …
disease status in patients with cancer, both in the early and advanced settings. The analysis …
Laboratory methods to decipher epigenetic signatures: a comparative review
R Halabian, V Arshad, A Ahmadi, P Saeedi… - Cellular & Molecular …, 2021 - Springer
Epigenetics refers to nucleotide sequence-independent events, and heritable changes,
including DNA methylation and histone modification (as the two main processes) …
including DNA methylation and histone modification (as the two main processes) …
[HTML][HTML] Vision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development …
HJ Yang, R Ratnapriya, T Cogliati, JW Kim… - Progress in retinal and …, 2015 - Elsevier
Genomics and genetics have invaded all aspects of biology and medicine, opening
uncharted territory for scientific exploration. The definition of “gene” itself has become …
uncharted territory for scientific exploration. The definition of “gene” itself has become …
Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs
The exact role of intragenic DNA methylation in regulating tissue-specific gene regulation is
unclear. Recently, the DNA-binding protein CTCF has been shown to participate in the …
unclear. Recently, the DNA-binding protein CTCF has been shown to participate in the …
A simple bridging flocculation assay for rapid, sensitive and stringent detection of gene specific DNA methylation
The challenge of bringing DNA methylation biomarkers into clinic is the lack of simple
methodologies as most current assays have been developed for research purposes. To …
methodologies as most current assays have been developed for research purposes. To …
DNA methylome analyses implicate fallopian tube epithelia as the origin for high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSC) is the most common and lethal form of epithelial
ovarian cancer (EOC). Two distinct tissues have been suggested as the tissue of origin …
ovarian cancer (EOC). Two distinct tissues have been suggested as the tissue of origin …