The proteins of mRNA modification: writers, readers, and erasers

MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …

Reading, writing and erasing mRNA methylation

S Zaccara, RJ Ries, SR Jaffrey - Nature reviews Molecular cell biology, 2019 - nature.com
RNA methylation to form N 6-methyladenosine (m6A) in mRNA accounts for the most
abundant mRNA internal modification and has emerged as a widespread regulatory …

The role of m6A RNA methylation in human cancer

XY Chen, J Zhang, JS Zhu - Molecular cancer, 2019 - Springer
Abstract N 6-methyladenosine (m 6 A) is identified as the most common, abundant and
conserved internal transcriptional modification, especially within eukaryotic messenger …

Targeting cancer vulnerabilities with high-dose vitamin C

B Ngo, JM Van Riper, LC Cantley, J Yun - Nature Reviews Cancer, 2019 - nature.com
Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …

Means, mechanisms and consequences of adenine methylation in DNA

K Boulias, EL Greer - Nature Reviews Genetics, 2022 - nature.com
Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

LE Dorn, L Lasman, J Chen, X Xu, TJ Hund… - Circulation, 2019 - Am Heart Assoc
Background: N 6-Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …

N6-methyladenosine links RNA metabolism to cancer progression

D Dai, H Wang, L Zhu, H Jin, X Wang - Cell death & disease, 2018 - nature.com
Abstract N6-methyladenosine (m6A) is the most abundant mRNA modification. With the
development of antibody-based sequencing technologies and the findings of m6A-related …

Functions of N6-methyladenosine and its role in cancer

L He, H Li, A Wu, Y Peng, G Shu, G Yin - Molecular cancer, 2019 - Springer
Abstract N6-methyladenosine (m6A) is methylation that occurs in the N6-position of
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …

FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis

DY Ruan, T Li, YN Wang, Q Meng, Y Li, K Yu, M Wang… - Oncogene, 2021 - nature.com
Fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A)
demethylase, participates in tumor progression and metastasis in many malignancies, but its …

Naturally occurring modified ribonucleosides

PJ McCown, A Ruszkowska, CN Kunkler… - Wiley …, 2020 - Wiley Online Library
The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …