SUMOylation is a reversible post-translational modification which has emerged as a crucial
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …

Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …

Objective We investigated the effect and mechanism of hypoxic microenvironment and
hypoxia-inducible factors (HIFs) on hepatocellular carcinoma (HCC) cancer stemness …

The interactions and functions of protein inhibitors of activated STAT (PIAS) proteins are not
restricted to the signal transducers and activators of transcription (STATs), but PIAS1,-2,-3 …

NF-κB activation is a critical component in the transcriptional response to hypoxia. However,
the underlying mechanisms that control its activity under these conditions are unknown …

Protein ubiquitylation has emerged as an important regulatory mechanism that impacts
almost every aspect of the DNA damage response. In this review, we discuss how DNA …

Activation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α)-mediated
transcription is important for both the determination of mitochondrial content and the …

SUMOylation is a post-translational modification characterized by covalent and reversible
binding of small ubiquitin-like modifier (SUMO) to a target protein. In mammals, four different …

NF‐κB comprises a family of transcription factors that are critically involved in various
inflammatory processes. In this paper, the role of NF‐κB in inflammation and atherosclerosis …

The post-translational modification of proteins is critical for the spatial and temporal
regulation of signalling cascades. This is especially important in the CNS where the …