Metabolic reprogramming in immune response and tissue inflammation
Innate and adaptive immunity participate in and regulate numerous human diseases.
Increasing evidence implies that metabolic reprogramming mediates immune cell functional …
Increasing evidence implies that metabolic reprogramming mediates immune cell functional …
Epigenetic mechanisms regulating T-cell responses
During the last decade, advances in sequencing technologies allowed production of a
wealth of information on epigenetic modifications in T cells. Epigenome maps, in …
wealth of information on epigenetic modifications in T cells. Epigenome maps, in …
[HTML][HTML] Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
Background DNA methylation is one of the main epigenetic mechanisms for the regulation of
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
[HTML][HTML] Antigen receptor control of methionine metabolism in T cells
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support
the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell …
the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell …
[HTML][HTML] Epigenomic profiling of human CD4+ T cells supports a linear differentiation model and highlights molecular regulators of memory development
The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined.
We generated deep epigenomes comprising genome-wide profiles of DNA methylation …
We generated deep epigenomes comprising genome-wide profiles of DNA methylation …
Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis
M Zeitelhofer, MZ Adzemovic… - Proceedings of the …, 2017 - National Acad Sciences
Vitamin D exerts multiple immunomodulatory functions and has been implicated in the
etiology and treatment of several autoimmune diseases, including multiple sclerosis (MS) …
etiology and treatment of several autoimmune diseases, including multiple sclerosis (MS) …
[HTML][HTML] Insights into the role of DNA methylation in immune cell development and autoimmune disease
J Li, L Li, Y Wang, G Huang, X Li, Z Xie… - Frontiers in Cell and …, 2021 - frontiersin.org
To date, nearly 100 autoimmune diseases have been an area of focus, and these diseases
bring health challenges to approximately 5% of the population worldwide. As a type of …
bring health challenges to approximately 5% of the population worldwide. As a type of …
Epigenetic regulation of T cell memory: recalling therapeutic implications
DF Tough, I Rioja, LK Modis, RK Prinjha - Trends in immunology, 2020 - cell.com
Memory T cells possess functional differences from naïve T cells that powerfully contribute to
the efficiency of secondary immune responses. These abilities are imprinted during the …
the efficiency of secondary immune responses. These abilities are imprinted during the …
Inducible chromatin priming is associated with the establishment of immunological memory in T cells
Immunological memory is a defining feature of vertebrate physiology, allowing rapid
responses to repeat infections. However, the molecular mechanisms required for its …
responses to repeat infections. However, the molecular mechanisms required for its …
[HTML][HTML] DNA methylation and immune memory response
NN Mittelstaedt, AL Becker, DN de Freitas, RF Zanin… - Cells, 2021 - mdpi.com
The generation of memory is a cardinal feature of the adaptive immune response, involving
different factors in a complex process of cellular differentiation. This process is essential for …
different factors in a complex process of cellular differentiation. This process is essential for …