Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …

Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular
and cellular specializations. To explore genomic mechanisms that control this specialization …

DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …

Chromatin modifications regulate genome function by recruiting proteins to the genome.
However, the protein composition at distinct chromatin modifications has yet to be fully …

Epigenetic alteration has been proposed to give rise to numerous classic hallmarks of
cancer. Impaired DNA methylation plays a central role in the onset and progression of …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Sophisticated gene-regulatory mechanisms probably evolved in prokaryotes billions of
years before the emergence of modern eukaryotes, which inherited the same basic …

Abstract Cancer-associated fibroblasts (CAFs), a significant component of the tumor
microenvironment (TME), contribute to cancer progression through the secretion of …

Active DNA demethylation is required for sexual reproduction in plants but the molecular
determinants underlying this epigenetic control are not known. Here, we show in …