DNA methylation in insects is integral to cellular differentiation, development, gene
regulation, genome integrity, and phenotypic plasticity. However, its evolutionary potential …

Two major issues are involved in clinical atherosclerosis treatment. First, there are no
significant clinical markers for early diagnosis of atherosclerosis. Second, the plaque will not …

Micro RNA‐29b (miR‐29b) is a member of the miR‐29 family, which targets DNA
methyltransferases (DNMT s) and ten eleven translocation enzymes (TET s), thereby …

Abstract Background Systemic sclerosis (SSc) is a rare autoimmune fibrosing disease with
an incompletely understood genetic and non-genetic etiology. Defining its etiology is …

Autoimmune diseases are enigmatic and complex, and most been associated with
epigenetic changes. Epigenetics describes changes in gene expression related to …

Abstract The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all
AML patients. DNMT3A is active as tetramer and the R882H mutation is located in one of the …

Hormones control developmental and physiological processes, often by regulating the
expression of multiple genes simultaneously or sequentially. Crosstalk between hormones …

Although intratumoral heterogeneity has been established in pediatric central nervous
system tumors, epigenomic alterations at the cell type level have largely remained …

ABSTRACT DNA methylation can affect tissue-specific gene transcription in ways that are
difficult to discern from studies focused on genome-wide analyses of differentially …

Large body of animal work and emerging clinical findings have suggested that early
exposure to anesthetics may result in increased risk of learning disabilities and behavioral …