Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer
WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
Sensitivity of transcription factors to DNA methylation
Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …
states throughout organism development. Epigenetics modifications, such as DNA …
Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular
and cellular specializations. To explore genomic mechanisms that control this specialization …
and cellular specializations. To explore genomic mechanisms that control this specialization …
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
ChromID identifies the protein interactome at chromatin marks
R Villaseñor, R Pfaendler, C Ambrosi, S Butz… - Nature …, 2020 - nature.com
Chromatin modifications regulate genome function by recruiting proteins to the genome.
However, the protein composition at distinct chromatin modifications has yet to be fully …
However, the protein composition at distinct chromatin modifications has yet to be fully …
Oncogenic roles and inhibitors of DNMT1, DNMT3A, and DNMT3B in acute myeloid leukaemia
Epigenetic alteration has been proposed to give rise to numerous classic hallmarks of
cancer. Impaired DNA methylation plays a central role in the onset and progression of …
cancer. Impaired DNA methylation plays a central role in the onset and progression of …
Epigenetics in teleost fish: From molecular mechanisms to physiological phenotypes
While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …
phenotypes in mammalian research models across different developmental and …
Old cogs, new tricks: the evolution of gene expression in a chromatin context
Sophisticated gene-regulatory mechanisms probably evolved in prokaryotes billions of
years before the emergence of modern eukaryotes, which inherited the same basic …
years before the emergence of modern eukaryotes, which inherited the same basic …
Epigenetic regulation of cancer-associated fibroblast heterogeneity
RJ Kehrberg, N Bhyravbhatla, SK Batra… - Biochimica et Biophysica …, 2023 - Elsevier
Abstract Cancer-associated fibroblasts (CAFs), a significant component of the tumor
microenvironment (TME), contribute to cancer progression through the secretion of …
microenvironment (TME), contribute to cancer progression through the secretion of …
Male fertility in Arabidopsis requires active DNA demethylation of genes that control pollen tube function
S Khouider, F Borges, C LeBlanc, A Ungru… - Nature …, 2021 - nature.com
Active DNA demethylation is required for sexual reproduction in plants but the molecular
determinants underlying this epigenetic control are not known. Here, we show in …
determinants underlying this epigenetic control are not known. Here, we show in …