Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD

P Kachroo, JD Morrow, AT Kho… - European …, 2020 - Eur Respiratory Soc
COPD likely has developmental origins; however, the underlying molecular mechanisms are
not fully identified. Investigation of lung tissue-specific epigenetic modifications such as DNA …

DNA methylation in adults and during development of the self‐fertilizing mangrove rivulus, Kryptolebias marmoratus

A Fellous, T Labed‐Veydert, M Locrel… - Ecology and …, 2018 - Wiley Online Library
In addition to genetic variation, epigenetic mechanisms such as DNA methylation might
make important contributions to heritable phenotypic diversity in populations. However, it is …

Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung

R Zakarya, I Adcock, BG Oliver - Clinical epigenetics, 2019 - Springer
In utero exposure to tobacco products, whether maternal or environmental, have harmful
effects on first neonatal and later adult respiratory outcomes. These effects have been …

Deconstruction of DNA methylation patterns during myogenesis reveals specific epigenetic events in the establishment of the skeletal muscle lineage

E Carrio, A Díez‐Villanueva, S Lois, I Mallona… - Stem Cells, 2015 - academic.oup.com
The progressive restriction of differentiation potential from pluripotent embryonic stem cells
(ESCs) to tissue‐specific stem cells involves widespread epigenetic reprogramming …

Integrative analysis of methylome and transcriptome in human blood identifies extensive sex-and immune cell-specific differentially methylated regions

S Mamrut, N Avidan, E Staun-Ram, E Ginzburg… - Epigenetics, 2015 - Taylor & Francis
The relationship between DNA methylation and gene expression is complex and elusive. To
further elucidate these relations, we performed an integrative analysis of the methylome and …

Genome-wide analysis of DNA methylation in pigs using reduced representation bisulfite sequencing

M Choi, J Lee, MT Le, DT Nguyen, S Park… - DNA …, 2015 - academic.oup.com
DNA methylation plays a major role in the epigenetic regulation of gene expression.
Although a few DNA methylation profiling studies of porcine genome which is one of the …

DNA methylation: an epigenetic risk factor in preterm birth

R Menon, KN Conneely, AK Smith - Reproductive sciences, 2012 - journals.sagepub.com
Spontaneous preterm birth (PTB; birth prior to 37 weeks of gestation) is a complex
phenotype with multiple risk factors that complicate our understanding of its etiology. A …

DNA methylation markers in the postnatal developing rat brain

RK Simmons, SA Stringfellow, ME Glover, AA Wagle… - Brain research, 2013 - Elsevier
In spite of intense interest in how altered epigenetic processes including DNA methylation
may contribute to psychiatric and neurodevelopmental disorders, there is a limited …

Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs

J Wan, VF Oliver, H Zhu, DJ Zack, J Qian… - Nucleic acids …, 2013 - academic.oup.com
The exact role of intragenic DNA methylation in regulating tissue-specific gene regulation is
unclear. Recently, the DNA-binding protein CTCF has been shown to participate in the …

Spatiotemporal specificity of correlated DNA methylation and gene expression pairs across different human tissues and stages of brain development

K Wang, R Dai, Y Xia, J Tian, C Jiao, T Mikhailova… - Epigenetics, 2022 - Taylor & Francis
ABSTRACT DNA methylation (DNAm) that occurs on promoter regions is primarily
considered to repress gene expression. Previous studies indicated that DNAm could also …