This review describes the various manifestations of the pyrimidine system (alkylated,
glycosylated, benzo‐annelated.). These comprise pyrimidine nucleosides as well as …

Oxidative DNA damage is a major cause of cell death and mutagenesis in all aerobic
organisms, and several new oxidative base lesions have been identified in recent years …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

The mechanisms that establish and maintain methylation patterns in the mammalian
genome are very poorly understood, even though perturbations of methylation patterns lead …

Changes in the pattern of DNA methylation have been a consistent finding in cancer cells.
The mostly descriptive nature of these studies and the fact that both hypo-and …

Mammals have long been known to tag their DNA by the addition of methyl groups to
cytosine residues. Only quite recently, however, has the functional significance of DNA …

The modern drug discovery process has largely focused its attention in the so-called magic
bullets, single chemical entities that exhibit high selectivity and potency for a particular …

Many organisms expand the information content of their genome through enzymatic meth
ation of cytosine meld&me. Here we report the 2.8 x'cryetal etructure of a bacterial DNA …

Double-stranded RNA (dsRNA)-specific adenosine deaminase converts adenosine to
inosine in dsRNA. The protein has been purified from calf thymus, and here we describe the …

Enzymatic methylation of DNA plays important roles in both prokaryotes and eukaryotes.
Structural study of the Hhal DNA methyltransferase has provided considerable insight into …