Atherosclerosis (AS) is a chronic inflammatory disease accompanied by complex
pathological changes, such as endothelial dysfunction, foam cell formation, and vascular …

This is an exciting time in the study of Friedreich's ataxia. Over the last 10 years much
progress has been made in uncovering the mechanisms, whereby the Frataxin gene is …

An array of oncogenic histone point mutations have been identified across a number of
different cancer studies. It has been suggested that some of these mutant histones can exert …

Aberrant DNA methylation is a hallmark of cancer. However, our understanding of how
tumor cell-specific DNA methylation patterns are established and maintained is limited …

Dicer participates in heterochromatin formation in fission yeast and plants. However,
whether it has a similar role in mammals remains controversial. Here we showed that the …

RNA interference is required for post-transcriptional silencing, but also has additional roles
in transcriptional silencing of centromeres and genome stability. However, these roles have …

Systemic lupus erythematosus (SLE) is a chronic, multi-system autoimmune disease
characterized by disorder of the generation of auto-antibodies to components of cell …

MicroRNAs post-transcriptionally regulate the expression of approximately 60% of the
mammalian genes, and have an important role in maintaining the differentiated state of …

This report is the outcome of an EFSA procurement aiming at investigating and summarising
the state of knowledge on (I) the mode-of-action of dsRNA and miRNA pathways,(II) the …

In most mouse tissues, long-interspersed elements-1 (L1s) are silenced via methylation of
their 5′-untranslated regions (5′-UTR). A gradual loss-of-methylation in pre-implantation …