Obesity has become a global epidemic that has a negative impact on population health and
the economy of nations. Genetic predispositions have been demonstrated to have a …

Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …

The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and
treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation …

Women have more body fat than men, but in contrast to the deleterious metabolic
consequences of the central obesity typical of men, the pear-shaped body fat distribution of …

Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

Background: Recent technological advances in epigenome profiling have led to an
increasing number of studies investigating the role of the epigenome in obesity. There is …

Given the anthropometric differences between men and women and previous evidence of
sex-difference in genetic effects, we conducted a genome-wide search for sexually …

Integrating the genotype with epigenetic marks holds the promise of better understanding
the biology that underlies the complex interactions of inherited and environmental …

The response to exercise training (trainability) has been shown to have a strong heritable
component. There is growing evidence suggesting that traits such as trainability do not only …

Pharmacological response depends on multiple factors and one of them is sex–gender.
Data on the specific effects of sex–gender on pharmacokinetics, as well as the safety and …