[HTML][HTML] Advances in single-cell omics and multiomics for high-resolution molecular profiling
J Lim, C Park, M Kim, H Kim, J Kim… - Experimental & Molecular …, 2024 - nature.com
Single-cell omics technologies have revolutionized molecular profiling by providing high-
resolution insights into cellular heterogeneity and complexity. Traditional bulk omics …
resolution insights into cellular heterogeneity and complexity. Traditional bulk omics …
Single-cell multi-omics sequencing and its application in tumor heterogeneity
Y Sun, Z Liu, Y Fu, Y Yang, J Lu, M Pan… - Briefings in …, 2023 - academic.oup.com
In recent years, the emergence and development of single-cell sequencing technologies
have provided unprecedented opportunities to analyze deoxyribonucleic acid, ribonucleic …
have provided unprecedented opportunities to analyze deoxyribonucleic acid, ribonucleic …
Tracking early mammalian organogenesis–prediction and validation of differentiation trajectories at whole organism scale
I Imaz-Rosshandler, C Rode, C Guibentif… - …, 2024 - journals.biologists.com
Early organogenesis represents a key step in animal development, during which pluripotent
cells diversify to initiate organ formation. Here, we sampled 300,000 single-cell …
cells diversify to initiate organ formation. Here, we sampled 300,000 single-cell …
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation
M Schulz, A Teissandier… - Nature Structural & …, 2024 - nature.com
As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early
mammalian development, they acquire high DNA methylation levels. During this transition …
mammalian development, they acquire high DNA methylation levels. During this transition …
Mammalian DNA methylome dynamics: mechanisms, functions and new frontiers
ABSTRACT DNA methylation is a highly conserved epigenetic modification that plays
essential roles in mammalian gene regulation, genome stability and development. Despite …
essential roles in mammalian gene regulation, genome stability and development. Despite …
Loss of DNA methylation disrupts syncytiotrophoblast development: Proposed consequences of aberrant germline gene activation
G Lea, CW Hanna - BioEssays, 2024 - Wiley Online Library
DNA methylation is a repressive epigenetic modification that is essential for development
and its disruption is widely implicated in disease. Yet, remarkably, ablation of DNA …
and its disruption is widely implicated in disease. Yet, remarkably, ablation of DNA …
[HTML][HTML] Integrative single-cell RNA-Seq and ATAC-seq analysis of mouse corneal epithelial cells
ZJ Lu, JG Ye, DL Wang, MK Li… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: Corneal epithelial homeostasis is maintained by coordinated gene expression
across distinct cell populations, but the gene regulatory programs underlying this cellular …
across distinct cell populations, but the gene regulatory programs underlying this cellular …
Dynamic DNA methylation turnover at the exit of pluripotency epigenetically primes gene regulatory elements for hematopoietic lineage specification
Epigenetic mechanisms govern developmental cell fate decisions, but how DNA methylation
coordinates with chromatin structure and three-dimensional DNA folding to enact cell-type …
coordinates with chromatin structure and three-dimensional DNA folding to enact cell-type …
[HTML][HTML] 动物早期胚胎发育中表观重编程的机制
余彤， 任斌斌， 郑睿智， 朱文治， 苏建民 - 畜牧兽医学报, 2023 - html.rhhz.net
哺乳动物早期胚胎发育过程中, 受精卵经历了一系列表观遗传重编程事件,
去除了雌雄原核的表观遗传记忆, 从而建立了胚胎的全能性. 然而, 这些重编程事件的进行必须 …
去除了雌雄原核的表观遗传记忆, 从而建立了胚胎的全能性. 然而, 这些重编程事件的进行必须 …
DNA methylation and cell fate in mouse embryos
D Clyde - Nature Reviews Genetics, 2022 - nature.com
In brIef Page 1 Nature reviews | Genetics 0123456789();: Regrettably, European and
European-descent ancestries continue to dominate human genetic databases. With the …
European-descent ancestries continue to dominate human genetic databases. With the …