Base editing—the introduction of single-nucleotide variants (SNVs) into DNA or RNA in
living cells—is one of the most recent advances in the field of genome editing. As around …

Hearing loss caused by exposure to recreational and occupational noise remains a
worldwide disabling condition and dysregulation of redox homeostasis is the hallmark of …

Recent work suggests that hair cells are not the most vulnerable elements in the inner ear;
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …

The mammalian cochlea cannot regenerate functional hair cells (HCs) spontaneously.
Atoh1 overexpression as well as other strategies are unable to generate functional HCs …

Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high
percentage of the population. Currently, no approach exists to obtain large numbers of …

Inner ear sensory epithelia contain mechanosensitive hair cells that transmit information to
the brain through innervation with bipolar neurons. Mammalian hair cells do not regenerate …

Hearing loss is the most frequent sensory disorder in humans. Auditory hair cells (HCs) are
postmitotic at late-embryonic differentiation and postnatal stages, and their damage is the …

Hair cells (HCs) in mammals cannot spontaneously regenerate after damage. Atoh1
overexpression can promote HC regeneration in the postnatal cochlea, but the regenerated …

Sensorineural hearing loss is typically caused by damage to the cochlear hair cells (HCs)
due to external stimuli or because of one's genetic factors and the inability to convert sound …

Sensorineural deafness in mammals is most commonly caused by damage to inner ear
sensory epithelia, or hair cells, and can be attributed to genetic and environmental causes …