Maternal obesity and fetal metabolic programming: a fertile epigenetic soil

MJR Heerwagen, MR Miller… - American Journal of …, 2010 - journals.physiology.org
The incidence of obesity and overweight has reached epidemic levels in the United States
and developed countries worldwide. Even more alarming is the increasing prevalence of …

Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives

FI Milagro, ML Mansego, C De Miguel… - Molecular aspects of …, 2013 - Elsevier
Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …

[HTML][HTML] Developmental programming in response to maternal overnutrition

MZ Alfaradhi, SE Ozanne - Frontiers in genetics, 2011 - frontiersin.org
Metabolic disorders have seen an increased prevalence in recent years in developed as
well as developing countries. While it is clear lifestyle choices and habits have contributed to …

[HTML][HTML] Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways

L Dearden, S Buller, IC Furigo… - Molecular …, 2020 - Elsevier
Objective Perinatal exposure to maternal obesity results in predisposition of offspring to
develop obesity later in life. Increased weight gain in offspring exposed to maternal obesity …

[HTML][HTML] Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood

HS Bhatia, R Agrawal, S Sharma, YX Huo, Z Ying… - PloS one, 2011 - journals.plos.org
Omega-3-fatty acid DHA is a structural component of brain plasma membranes, thereby
crucial for neuronal signaling; however, the brain is inefficient at synthesizing DHA. We have …

Metabolic programming of long‐term outcomes due to fatty acid nutrition in early life

SM Innis - Maternal & child nutrition, 2011 - Wiley Online Library
Understanding of the importance of dietary fatty acids has grown beyond a simple source of
energy to complex roles in regulating gene expression and cell and intracellular …

Early life origins of metabolic disease: developmental programming of hypothalamic pathways controlling energy homeostasis

L Dearden, SE Ozanne - Frontiers in neuroendocrinology, 2015 - Elsevier
A wealth of animal and human studies demonstrate that perinatal exposure to adverse
metabolic conditions–be it maternal obesity, diabetes or under-nutrition–results in …

[HTML][HTML] Do fatty acids affect fetal programming?

S Kabaran, HT Besler - Journal of Health, Population and Nutrition, 2015 - Springer
Background In this study discussed the primary and regulatory roles of fatty acids, and
investigated the affects of fatty acids on metabolic programming. Methods Review of the …

Gestational overgrowth and undergrowth affect neurodevelopment: similarities and differences from behavior to epigenetics

NM Grissom, TM Reyes - International journal of developmental …, 2013 - Elsevier
The size of an infant at birth, a measure of gestational growth, has been recognized for many
years as a biomarker of future risk of morbidity. Both being born small for gestational age …

Maternal and postweaning high-fat diets disturb hippocampal gene expression, learning, and memory function

KC Page, EK Jones, EK Anday - American Journal of …, 2014 - journals.physiology.org
We tested the hypothesis that excess saturated fat consumption during pregnancy, lactation,
and/or postweaning alters the expression of genes mediating hippocampal synaptic efficacy …