Maternal obesity and fetal metabolic programming: a fertile epigenetic soil
MJR Heerwagen, MR Miller… - American Journal of …, 2010 - journals.physiology.org
The incidence of obesity and overweight has reached epidemic levels in the United States
and developed countries worldwide. Even more alarming is the increasing prevalence of …
and developed countries worldwide. Even more alarming is the increasing prevalence of …
Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives
FI Milagro, ML Mansego, C De Miguel… - Molecular aspects of …, 2013 - Elsevier
Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …
[HTML][HTML] Developmental programming in response to maternal overnutrition
MZ Alfaradhi, SE Ozanne - Frontiers in genetics, 2011 - frontiersin.org
Metabolic disorders have seen an increased prevalence in recent years in developed as
well as developing countries. While it is clear lifestyle choices and habits have contributed to …
well as developing countries. While it is clear lifestyle choices and habits have contributed to …
[HTML][HTML] Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways
L Dearden, S Buller, IC Furigo… - Molecular …, 2020 - Elsevier
Objective Perinatal exposure to maternal obesity results in predisposition of offspring to
develop obesity later in life. Increased weight gain in offspring exposed to maternal obesity …
develop obesity later in life. Increased weight gain in offspring exposed to maternal obesity …
[HTML][HTML] Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood
Omega-3-fatty acid DHA is a structural component of brain plasma membranes, thereby
crucial for neuronal signaling; however, the brain is inefficient at synthesizing DHA. We have …
crucial for neuronal signaling; however, the brain is inefficient at synthesizing DHA. We have …
Metabolic programming of long‐term outcomes due to fatty acid nutrition in early life
SM Innis - Maternal & child nutrition, 2011 - Wiley Online Library
Understanding of the importance of dietary fatty acids has grown beyond a simple source of
energy to complex roles in regulating gene expression and cell and intracellular …
energy to complex roles in regulating gene expression and cell and intracellular …
Early life origins of metabolic disease: developmental programming of hypothalamic pathways controlling energy homeostasis
A wealth of animal and human studies demonstrate that perinatal exposure to adverse
metabolic conditions–be it maternal obesity, diabetes or under-nutrition–results in …
metabolic conditions–be it maternal obesity, diabetes or under-nutrition–results in …
[HTML][HTML] Do fatty acids affect fetal programming?
Background In this study discussed the primary and regulatory roles of fatty acids, and
investigated the affects of fatty acids on metabolic programming. Methods Review of the …
investigated the affects of fatty acids on metabolic programming. Methods Review of the …
Gestational overgrowth and undergrowth affect neurodevelopment: similarities and differences from behavior to epigenetics
NM Grissom, TM Reyes - International journal of developmental …, 2013 - Elsevier
The size of an infant at birth, a measure of gestational growth, has been recognized for many
years as a biomarker of future risk of morbidity. Both being born small for gestational age …
years as a biomarker of future risk of morbidity. Both being born small for gestational age …
Maternal and postweaning high-fat diets disturb hippocampal gene expression, learning, and memory function
KC Page, EK Jones, EK Anday - American Journal of …, 2014 - journals.physiology.org
We tested the hypothesis that excess saturated fat consumption during pregnancy, lactation,
and/or postweaning alters the expression of genes mediating hippocampal synaptic efficacy …
and/or postweaning alters the expression of genes mediating hippocampal synaptic efficacy …