Lung cancer is the leading cause of cancer death worldwide, accounting for more deaths
than breast, prostate and colon cancer combined. While treatment decisions are determined …

Simple Summary Aberrant DNA methylation is associated with multiple malignancies,
including lung cancer. Differences in methylation patterns have been observed across lung …

Purpose Non–small-cell lung cancer (NSCLC) is a tumor in which only small improvements
in clinical outcome have been achieved. The issue is critical for stage I patients for whom …

Sample heterogeneity often masks DNA methylation signatures in subpopulations of cells.
Here, we present a method to genotype single cells while simultaneously interrogating gene …

Chronic obstructive pulmonary disease (COPD) is one of the most prevalent chronic adult
diseases, with significant worldwide morbidity and mortality. Although long-term tobacco …

Epigenetic research has the potential to improve our understanding of the pathogenesis of
cancer, specifically non-small-cell lung cancer, and support our efforts to personalize the …

Background: Aberrant DNA methylation occurs commonly during carcinogenesis and is of
clinical value in human cancers. However, knowledge of the impact of DNA methylation …

HOX genes are commonly known for their role in embryonic development, defining the
positional identity of most structures along the anterior–posterior axis. In postembryonic life …

Numerous researches have focused on the genetic variations affecting SARS-CoV-2
infection, whereas the epigenetic effects are inadequately described. In this report, for the …

Background DNA methylation alterations are early events in tumorigenesis and important in
the regulation of gene expression in cancer cells. Lung cancer patients have in general a …