The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

An important factor in the transition from an open to a closed circulatory system was a
change in vessel wall structure and composition that enabled the large arteries to store and …

The Ehlers–Danlos syndromes (EDSs) comprise a heterogeneous group of diseases,
characterized by fragility of the soft connective tissues and widespread manifestations in …

Human skin consists of a stratified, cellular epidermis and an underlying dermis of
connective tissue [1–5]. The dermal–epidermal junction is undulating in section; ridges of …

Summary Background Vascular Ehlers-Danlos syndrome is a rare severe disease that
causes arterial dissections and ruptures that can lead to early death. No preventive …

Abstract Vascular Ehlers–Danlos syndrome (vEDS) is a rare and severe autosomal
dominant disorder caused by variants at the COL3A1 gene. Clinical characteristics and …

GPR56, an orphan G protein-coupled receptor (GPCR) from the family of adhesion GPCRs,
plays an indispensable role in cortical development and lamination. Mutations in the GPR56 …

Summary The Ehlers‐Danlos syndrome (EDS) is a heterogeneous group of heritable
disorders of connective tissue characterized by articular hypermobility, skin …

Thoracic aortic aneurysm and dissection (TAAD) affects many patients globally and has high
mortality rates if undetected. Once thought to be solely a degenerative disease that afflicted …

Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS), is an
inherited connective tissue disorder defined by characteristic facial features (acrogeria) in …