[HTML][HTML] Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases

SW Bothwell, D Janigro, A Patabendige - Fluids and Barriers of the CNS, 2019 - Springer
The fine balance between the secretion, composition, volume and turnover of cerebrospinal
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …

[HTML][HTML] Choroid plexus aquaporins in CSF homeostasis and the glymphatic system: Their relevance for Alzheimer's disease

C Municio, L Carrero, D Antequera, E Carro - International Journal of …, 2023 - mdpi.com
The glymphatic system, a fluid-clearance pathway involved in brain waste clearance, is
known to be impaired in neurological disorders, including Alzheimer's disease (AD). For this …

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

RS Gomolka, LM Hablitz, H Mestre, M Giannetto, T Du… - Elife, 2023 - elifesciences.org
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …

A clinical primer for the glymphatic system

LP Carlstrom, A Eltanahy, A Perry, AA Rabinstein… - Brain, 2022 - academic.oup.com
The complex and dynamic system of fluid flow through the perivascular and interstitial
spaces of the CNS has new-found implications for neurological diseases. CSF movement …

Delayed clearance of cerebrospinal fluid tracer from choroid plexus in idiopathic normal pressure hydrocephalus

PK Eide, LM Valnes, AH Pripp… - Journal of Cerebral …, 2020 - journals.sagepub.com
Impaired clearance of amyloid-β from choroid plexus is one proposed mechanism behind
amyloid deposition in Alzheimer's disease. The present study examined whether clearance …

The impact of hypoxia on blood-brain, blood-CSF, and CSF-brain barriers

JF Dunn, AM Isaacs - Journal of Applied Physiology, 2021 - journals.physiology.org
The blood-brain barrier (BBB), blood-cerebrospinal fluid (CSF) barrier (BCSFB), and CSF-
brain barriers (CSFBB) are highly regulated barriers in the central nervous system …

[HTML][HTML] AQP1 and AQP4 contribution to cerebrospinal fluid homeostasis

JL Trillo-Contreras, JJ Toledo-Aral, M Echevarría… - Cells, 2019 - mdpi.com
Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4
(AQP4) present in ependymal cells and glia limitants have been proposed to play a …

[HTML][HTML] Why is delirium more frequent in the elderly?

O Bugiani - Neurological Sciences, 2021 - Springer
An aging-related reduction in the brain's functional reserve may explain why delirium is
more frequent in the elderly than in younger people insofar as the reserve becomes …

[HTML][HTML] Cellular distribution of brain aquaporins and their contribution to cerebrospinal fluid homeostasis and hydrocephalus

JL Trillo-Contreras, R Ramírez-Lorca, J Villadiego… - Biomolecules, 2022 - mdpi.com
Brain aquaporins facilitate the movement of water between the four water compartments:
blood, cerebrospinal fluid, interstitial fluid, and intracellular fluid. This work analyzes the …

Regulation of aquaporin‐4 expression in the central nervous system investigated using M23‐AQP4 null mouse

F Pisani, L Simone, MG Mola, M De Bellis, A Frigeri… - Glia, 2021 - Wiley Online Library
In astrocytes, unknown mechanisms regulate the expression of M1 and M23 isoforms of
water channel aquaporin‐4 (M1‐AQP4 and M23‐AQP4). The ratio between these two …