Several types of epigenetic marks facilitate the complex patterning required for normal
human development. These epigenetic marks include DNA methylation at CpG …

Epigenetic mechanisms, often defined as regulating gene activity independently of
underlying DNA sequence, are crucial for healthy development. The sum total of epigenetic …

Gamete and early embryo development are important stages when genome-scale
epigenetic transitions are orchestrated. The apparent lack of remodeling of differential …

A societal preference of delaying maternal age at first childbirth has increased reliance on
assisted reproductive technologies/therapies (ART) to conceive a child. Oocytes that have …

Objective To examine whether mouse oocytes vitrification could alter the deoxyribonucleic
acid (DNA) methylation of differentially methylated regions (DMRs) of three imprinted genes …

DNA cytosine methylation (5mC) is indispensable for a number of cellular processes,
including retrotransposon silencing, genomic imprinting, and X chromosome inactivation in …

A cultural trend in developed countries is favoring a delay in maternal age at first childbirth.
In mammals fertility and chronological age show an inverse correlation. Oocyte quality is a …

It has been demonstrated that reprogramming factors are sequestered in the pronuclei of
zygotes after fertilization, because zygotes enucleated at the M phase instead of interphase …

DNA methylation and demethylation are opposing processes that when in balance create
stable patterns of epigenetic memory. The control of DNA methylation pattern formation by …

Expression and localization of mRNAs for vascular endothelial growth factor (VEGF), VEGF
receptor 1 (Flt) and VEGF receptor 2 (KDR)(VEGFR-1 and VEGFR-2, respectively) were …