Molecular pathogenesis of ADPKD: The polycystin complex gets complex. Autosomal-
dominant polycystic kidney disease (ADPKD) is one of the most common human monogenic …

Biologists have long known that humans experience their environment through cilia. Light,
odorant, and sound perception depend on these microtubule-filled, complex organelles …

The most severe form of autosomal dominant polycystic kidney disease occurs in patients
with mutations in the gene (PKD1) encoding polycystin-1 (PC1). PC1 is a complex polytopic …

The ubiquitous and highly conserved flotillin proteins, flotillin-1 and flotillin-2, have been
shown to be involved in various cellular processes such as cell adhesion, signal …

Significant progress in understanding the molecular mechanisms of polycystic kidney
disease (PKD) has been made in recent years. Translating this understanding into effective …

Abstract Polycystin-1 (PC1), the product of the PKD1 gene mutated in the majority of
autosomal dominant polycystic kidney disease (ADPKD) cases, undergoes a cleavage …

Polycystin-1 (PC1) has an essential function in renal tubular morphogenesis and disruption
of its function causes cystogenesis in human autosomal dominant polycystic kidney disease …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by large fluid-filled
cysts and progressive deterioration of renal function necessitating renal replacement …

The age on onset of decline in renal function and end-stage renal disease (ESRD) in
autosomal polycystic kidney disease (ADPKD) is highly variable and there are currently no …

111 МС Игнатова креатинин крови 540 мкмоль/л, метаболический ацидоз (pH 7, 27,
рO2 96 mm Hg, рCO2 29, 7 mm Hg, ВЕ–11, 7 мэкв/л), оптическая плотность мочи 1003 …