The current state and future directions of RNAi-based therapeutics
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
RNA interference technology in crop protection against arthropod pests, pathogens and nematodes
Scientists have made significant progress in understanding and unraveling several aspects
of double‐stranded RNA (dsRNA)‐mediated gene silencing during the last two decades …
of double‐stranded RNA (dsRNA)‐mediated gene silencing during the last two decades …
Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review
P Ranasinghe, ML Addison, JW Dear… - British Journal of …, 2023 - Wiley Online Library
Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the
expression of specific genes. RNA interference technology, using synthetic structurally well …
expression of specific genes. RNA interference technology, using synthetic structurally well …
[HTML][HTML] A perspective on RNAi-based biopesticides
SJ Fletcher, PT Reeves, BT Hoang… - Frontiers in plant …, 2020 - frontiersin.org
Sustainable agriculture relies on practices and technologies that combine effectiveness with
a minimal environmental footprint. RNA interference (RNAi), a eukaryotic process in which …
a minimal environmental footprint. RNA interference (RNAi), a eukaryotic process in which …
[HTML][HTML] Insight into the prospects for RNAi therapy of cancer
Z Tian, G Liang, K Cui, Y Liang, Q Wang, S Lv… - Frontiers in …, 2021 - frontiersin.org
RNA interference (RNAi), also known as gene silencing, is a biological process that
prevents gene expression in certain diseases such as cancer. It can be used to improve the …
prevents gene expression in certain diseases such as cancer. It can be used to improve the …
Role of miRNAs and siRNAs in biotic and abiotic stress responses of plants
B Khraiwesh, JK Zhu, J Zhu - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
Small, non-coding RNAs are a distinct class of regulatory RNAs in plants and animals that
control a variety of biological processes. In plants, several classes of small RNAs with …
control a variety of biological processes. In plants, several classes of small RNAs with …
RNA interference
GJ Hannon - nature, 2002 - nature.com
A conserved biological response to double-stranded RNA, known variously as RNA
interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …
interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …
[HTML][HTML] Small RNAs in plants: recent development and application for crop improvement
A Kamthan, A Chaudhuri, M Kamthan… - Frontiers in plant …, 2015 - frontiersin.org
The phenomenon of RNA interference (RNAi) which involves sequence-specific gene
regulation by small non-coding RNAs, ie, small interfering RNA (siRNA) and microRNA …
regulation by small non-coding RNAs, ie, small interfering RNA (siRNA) and microRNA …
RNAi technology: a new platform for crop pest control
B Mamta, MV Rajam - Physiology and Molecular Biology of Plants, 2017 - Springer
The insect pests are big threat in meeting the food demands for future generation. The
present pest control strategies, including the existing transgenic approaches show certain …
present pest control strategies, including the existing transgenic approaches show certain …
Clinical advances of siRNA therapeutics
B Hu, Y Weng, XH Xia, X Liang… - The journal of gene …, 2019 - Wiley Online Library
Small interfering RNA (siRNA) enables efficient target gene silencing by employing a RNA
interference (RNAi) mechanism, which can compromise gene expression and regulate gene …
interference (RNAi) mechanism, which can compromise gene expression and regulate gene …