The current state and future directions of RNAi-based therapeutics

RL Setten, JJ Rossi, S Han - Nature reviews Drug discovery, 2019 - nature.com
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …

RNA interference technology in crop protection against arthropod pests, pathogens and nematodes

M Zotti, EA Dos Santos, D Cagliari… - Pest management …, 2018 - Wiley Online Library
Scientists have made significant progress in understanding and unraveling several aspects
of double‐stranded RNA (dsRNA)‐mediated gene silencing during the last two decades …

Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review

P Ranasinghe, ML Addison, JW Dear… - British Journal of …, 2023 - Wiley Online Library
Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the
expression of specific genes. RNA interference technology, using synthetic structurally well …

[HTML][HTML] A perspective on RNAi-based biopesticides

SJ Fletcher, PT Reeves, BT Hoang… - Frontiers in plant …, 2020 - frontiersin.org
Sustainable agriculture relies on practices and technologies that combine effectiveness with
a minimal environmental footprint. RNA interference (RNAi), a eukaryotic process in which …

[HTML][HTML] Insight into the prospects for RNAi therapy of cancer

Z Tian, G Liang, K Cui, Y Liang, Q Wang, S Lv… - Frontiers in …, 2021 - frontiersin.org
RNA interference (RNAi), also known as gene silencing, is a biological process that
prevents gene expression in certain diseases such as cancer. It can be used to improve the …

Role of miRNAs and siRNAs in biotic and abiotic stress responses of plants

B Khraiwesh, JK Zhu, J Zhu - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
Small, non-coding RNAs are a distinct class of regulatory RNAs in plants and animals that
control a variety of biological processes. In plants, several classes of small RNAs with …

RNA interference

GJ Hannon - nature, 2002 - nature.com
A conserved biological response to double-stranded RNA, known variously as RNA
interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …

[HTML][HTML] Small RNAs in plants: recent development and application for crop improvement

A Kamthan, A Chaudhuri, M Kamthan… - Frontiers in plant …, 2015 - frontiersin.org
The phenomenon of RNA interference (RNAi) which involves sequence-specific gene
regulation by small non-coding RNAs, ie, small interfering RNA (siRNA) and microRNA …

RNAi technology: a new platform for crop pest control

B Mamta, MV Rajam - Physiology and Molecular Biology of Plants, 2017 - Springer
The insect pests are big threat in meeting the food demands for future generation. The
present pest control strategies, including the existing transgenic approaches show certain …

Clinical advances of siRNA therapeutics

B Hu, Y Weng, XH Xia, X Liang… - The journal of gene …, 2019 - Wiley Online Library
Small interfering RNA (siRNA) enables efficient target gene silencing by employing a RNA
interference (RNAi) mechanism, which can compromise gene expression and regulate gene …