As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of
cellular processes, including those involving vascular cells. This brief review summarizes …

Mast cells are immune cells of the myeloid lineage and are present in connective tissues
throughout the body. The activation and degranulation of mast cells significantly modulates …

Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

Conventional views of the tunica adventitia as a poorly organized layer of vessel wall
composed of fibroblasts, connective tissue, and perivascular nerves are undergoing …

Clinical observations and accumulating laboratory evidence support a complex interplay
between coagulation, inflammation, innate immunity and fibrinolysis in venous …

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
aminopeptidase. The best characterized physiological function of CatC is the activation of …

IgE has a key role in the pathogenesis of allergic responses through its ability to activate
mast cells via the receptor FcεR1. In addition to mast cells, many cell types implicated in …

Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

Mast cells, like many other types of inflammatory cell, perform pleiotropic roles in
cardiometabolic diseases such as atherosclerosis, abdominal aortic aneurysms, obesity …

Cardiovascular complications are extremely frequent in patients with chronic kidney disease
(CKD) and death from cardiac causes is the most common cause of death in this particular …