Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

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T-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in
cancer, but how tumor cells drive T-cell exhaustion remains elusive. Here, we find T-cell …

Objective Obesity and its associated comorbidities represent a global health challenge with
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …

Drug-induced liver injury (DILI) is an important clinical problem, which has received more
attention in recent decades. It can be induced by small chemical molecules, biological …

The emergence of large gene expression datasets has revealed the need for improved tools
to identify enriched gene categories and visualize enrichment patterns. While gene …

Every year almost 500,000 new patients are diagnosed with hepatocellular carcinoma
(HCC), a primary malignancy of the liver that is associated with a poor prognosis. Numerous …

S-adenosyl-l-methionine (SAMe; AdoMet) is an important, metabolically pleiotropic molecule
that participates in multiple cellular reactions as the precursor for the synthesis of glutathione …

Lifespan and metabolic health are influenced by dietary nutrients. Recent studies show that
a reduced protein intake or low-protein/high-carbohydrate diet plays a critical role in …