Intracytoplasmic sperm injection (ICSI) has become the most commonly used method of
fertilization in assisted reproductive technology. The primary reasons for its popularity stem …

BACKGROUND Increasing numbers of children are being conceived by assisted
reproductive technology (ART). A number of studies have highlighted an altered epigenetic …

Concerns have been raised about the health and development of children conceived by
assisted reproductive technologies (ART) since 1978. Controversially, ART has been linked …

ABSTRACT Children conceived by Assisted Reproductive Technologies (ART) are at
moderately increased risk for a number of undesirable outcomes, including low birth weight …

Background Births to subfertile women, with and without infertility treatment, have been
reported to have lower birthweights and shorter gestations, even when limited to singletons …

BACKGROUND The many manipulations and processes used in ART coincide with the
timing of epigenetic reprogramming and imprinting during female gametogenesis and pre …

BACKGROUND Genomic imprinting is an epigenetic gene regulatory mechanism; disruption
of this process during early embryonic development can have major consequences on both …

Early stages of mammalian embryonic development are now known to be very sensitive to
their microenvironment, with long term effects on fetal, postnatal, and adult health, thus …

DNA methylation can be considered a component of epigenetic memory with a critical role
during embryo development, and which undergoes dramatic reprogramming after …

Background Just under 3% of children in Germany, and approximately 6% of children in
some other countries, such as Denmark, are now being conceived with the aid of in vitro …