Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities

MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

[HTML][HTML] Circadian rhythms and mood disorders: Time to see the light

HK Dollish, M Tsyglakova, CA McClung - Neuron, 2024 - cell.com
The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

JY Hansen, G Shafiei, RD Markello, K Smart… - Nature …, 2022 - nature.com
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …

Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies

B Bi, D Che, Y Bai - Translational Psychiatry, 2022 - nature.com
Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in
three domains including emotional processing, cognitive processing, and psychomotor …

Schizophrenia, bipolar and major depressive disorders: overview of clinical features, neurotransmitter alterations, pharmacological interventions, and impact of …

PK Mandal, S Gaur, RG Roy, A Samkaria… - ACS Chemical …, 2022 - ACS Publications
Psychiatric disorders are one of the leading causes of disability worldwide and affect the
quality of life of both individuals and the society. The current understanding of these …

Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings

G Scaini, SS Valvassori, AP Diaz, CN Lima… - Brazilian Journal of …, 2020 - SciELO Brasil
Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that
alternate between mania and hypomania or between depression and mixed states, often …

Therapeutic interventions to mitigate mitochondrial dysfunction and oxidative stress–induced damage in patients with bipolar disorder

S Madireddy, S Madireddy - International Journal of Molecular Sciences, 2022 - mdpi.com
Bipolar disorder (BD) is characterized by mood changes, including recurrent manic,
hypomanic, and depressive episodes, which may involve mixed symptoms. Despite the …

Ion channels and transporters as therapeutic agents: from biomolecules to supramolecular medicinal chemistry

G Picci, S Marchesan, C Caltagirone - Biomedicines, 2022 - mdpi.com
Ion channels and transporters typically consist of biomolecules that play key roles in a large
variety of physiological and pathological processes. Traditional therapies include many ion …

Plasmalogen in the brain: Effects on cognitive functions and behaviors attributable to its properties

J Udagawa, K Hino - Brain research bulletin, 2022 - Elsevier
Ether phospholipid compositions are altered in the plasma or brain of patients with brain
disorders, such as Alzheimer and Parkinson's disease, including those with psychiatric …

GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice

H Yamamoto, HC Lee-Okada, M Ikeda… - Molecular …, 2023 - nature.com
Large-scale genome-wide association studies (GWASs) on bipolar disorder (BD) have
implicated the involvement of the fatty acid desaturase (FADS) locus. These enzymes …