Cardiovascular disease (CVD) is a group of systemic disorders threatening human health
with complex pathogenesis, among which mitochondrial energy metabolism reprogramming …

There is increasing evidence for enhanced oxidative stress in the vascular wall of abdominal
aortic aneurysms (AAA). Mitochondrial damage and dysfunction are hypothesized to be …

Angiotensin II (AngII) induces disruption of mitochondrial homeostasis and oxidative stress.
Nuclear receptor NR4A1 (Nur77) plays an important role in vascular smooth muscle cells …

The antibiotic doxycycline is known to inhibit inflammation and was therefore considered as
a therapeutic to prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial …

Aim Signal transducer and activator of transcription (STAT) signaling is critical for the
pathogenesis of abdominal aortic aneurysms (AAAs). Though protein inhibitor of activated …

Background Rupture of abdominal aortic aneurysm (rAAA) is a fatal event in the elderly.
Elevated blood pressure and weakening of vessel wall strength are major risk factors for this …

Abdominal aortic aneurysm (AAA) is typically asymptomatic but a devastating cardiovascular
disorder, with overall mortality exceeding 80% once it ruptures. Some patients with AAA may …

Background: Abdominal aortic aneurysms (AAA) are focal dilatations of the abdominal aorta.
They are normally asymptomatic and expand progressively, increasing their risk of rupture …

Introduction The prevalence of abdominal aortic aneurysm (AAA) is constantly progressing
with the aging of the global population. AAA rupture has a devastating 80% mortality rate …

Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine
2058. 65 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-2154-7. Abdominal …