The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Background Development of the placenta during the late first trimester is critical to ensure
normal growth and development of the fetus. Developmental differences in this window such …

There is growing evidence of long-term cardiovascular sequelae in children after in utero
exposure to preeclampsia. Maternal hypertension and/or placental ischaemia during …

Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy
outcomes. It is known that GDM is associated with an altered placental function and changes …

The placenta is vital for fetal growth, and compromised function is associated with abnormal
development, especially of the brain. Linking placental function to brain development is a …

Aim: To determine whether dynamic DNA methylation changes in the human placenta can
be used to predict gestational age. Materials & methods: Publicly available placental DNA …

Although male–female differences in placental structure and function have been observed,
little is understood about their molecular underpinnings. Here, we present a mega-analysis …

Background Maternal smoking during pregnancy (MSDP) affects development of multiple
organ systems including the placenta, lung, brain, and vasculature. In particular, children …