Biology and therapeutic targeting of vascular endothelial growth factor A
L Pérez-Gutiérrez, N Ferrara - Nature Reviews Molecular Cell Biology, 2023 - nature.com
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …
process in which several families of regulators have been implicated. Among these, vascular …
Angiogenesis after acute myocardial infarction
X Wu, MR Reboll, M Korf-Klingebiel… - Cardiovascular …, 2021 - academic.oup.com
Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …
Role of angiopoietin-2 in vascular physiology and pathophysiology
Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
Hypoxia: overview on hypoxia-mediated mechanisms with a focus on the role of HIF genes
AA Tirpe, D Gulei, SM Ciortea, C Crivii… - International journal of …, 2019 - mdpi.com
Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …
development of the neoplastic disease. This review will discuss the means by which hypoxia …
Hypoxia: the cornerstone of glioblastoma
M Domènech, A Hernández, A Plaja… - International journal of …, 2021 - mdpi.com
Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the
presence of hypervascularization and necrosis, both caused by a hypoxic …
presence of hypervascularization and necrosis, both caused by a hypoxic …
[HTML][HTML] Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
C Wigerup, S Påhlman, D Bexell - Pharmacology & therapeutics, 2016 - Elsevier
Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …
Exploring the role of RGD-recognizing integrins in cancer
M Nieberler, U Reuning, F Reichart, J Notni, HJ Wester… - Cancers, 2017 - mdpi.com
Integrins are key regulators of communication between cells and with their
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …
Hypoxia‐inducible factor‐1 in physiological and pathophysiological angiogenesis: applications and therapies
A Zimna, M Kurpisz - BioMed research international, 2015 - Wiley Online Library
The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …
Pharmacologic targeting of hypoxia-inducible factors
GL Semenza - Annual review of pharmacology and toxicology, 2019 - annualreviews.org
Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …