[HTML][HTML] Childhood and adolescent obesity: a review

AR Kansra, S Lakkunarajah, MS Jay - Frontiers in pediatrics, 2021 - frontiersin.org
Obesity is a complex condition that interweaves biological, developmental, environmental,
behavioral, and genetic factors; it is a significant public health problem. The most common …

[HTML][HTML] Obesity and female infertility: potential mediators of obesity's impact

DE Broughton, KH Moley - Fertility and sterility, 2017 - Elsevier
The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …

Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity

SE Hampl, SG Hassink, AC Skinner, SC Armstrong… - …, 2023 - publications.aap.org
The current and long-term health of 14.4 million children and adolescents is affected by
obesity, 1, 2 making it one of the most common pediatric chronic diseases. 3–5 Long …

[HTML][HTML] Excess body weight: Novel insights into its roles in obesity comorbidities

X Zhang, S Ha, HCH Lau, J Yu - Seminars in Cancer Biology, 2023 - Elsevier
Excess body weight is a global health problem due to sedentary lifestyle and unhealthy diet,
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

M Pigeyre, FT Yazdi, Y Kaur, D Meyre - Clinical science, 2016 - portlandpress.com
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian randomization …

MM Mendelson, RE Marioni, R Joehanes, C Liu… - PLoS …, 2017 - journals.plos.org
Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …

[HTML][HTML] Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity

D Val-Laillet, E Aarts, B Weber, M Ferrari… - NeuroImage: Clinical, 2015 - Elsevier
Functional, molecular and genetic neuroimaging has highlighted the existence of brain
anomalies and neural vulnerability factors related to obesity and eating disorders such as …

De novo identification of differentially methylated regions in the human genome

TJ Peters, MJ Buckley, AL Statham, R Pidsley… - Epigenetics & …, 2015 - Springer
Background The identification and characterisation of differentially methylated regions
(DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We …

Leptin resistance in obesity: an epigenetic landscape

AB Crujeiras, MC Carreira, B Cabia, S Andrade, M Amil… - Life sciences, 2015 - Elsevier
Leptin is an adipocyte-secreted hormone that inhibits food intake and stimulates energy
expenditure through interactions with neuronal pathways in the brain, particularly pathways …

Physical exercise as therapy for type 2 diabetes mellitus: From mechanism to orientation

D Yang, Y Yang, Y Li, R Han - Annals of nutrition and metabolism, 2019 - karger.com
Background: Exercise therapy plays an important role in the prevention and treatment of
type 2 diabetes (T2DM). The mechanism of exercise therapy in the improvement of …