Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

Y Caspi, CK Pantazopoulou, JJ Prompers… - Elife, 2023 - elifesciences.org
Intercellular signalling is an indispensable part of multicellular life. Understanding the
commonalities and differences in how signalling molecules function in two remote branches …

Circadian disruption and mental health: the chronotherapeutic potential of microbiome-based and dietary strategies

P Codoñer-Franch, M Gombert… - International Journal of …, 2023 - mdpi.com
Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle
may largely explain this trend. Impaired circadian rhythms are associated with mental …

[HTML][HTML] Melatonin, BAG-1 and cortisol circadian interactions in tumor pathogenesis and patterned immune responses

G Anderson - Exploration of targeted anti-tumor therapy, 2023 - ncbi.nlm.nih.gov
A dysregulated circadian rhythm is significantly associated with cancer risk, as is aging. Both
aging and circadian dysregulation show suppressed pineal melatonin, which is indicated in …

Current understanding of the roles of gut–brain Axis in the cognitive deficits caused by perinatal stress exposure

MR Rubinstein, AL Burgueño, S Quiroga, MR Wald… - Cells, 2023 - mdpi.com
The term 'perinatal environment'refers to the period surrounding birth, which plays a crucial
role in brain development. It has been suggested that dynamic communication between the …

Melatonin in health and disease: A perspective for livestock production

ZE Contreras-Correa, RD Messman, RM Swanson… - Biomolecules, 2023 - mdpi.com
Mounting evidence in the literature indicates an important role of endogenous and
exogenous melatonin in driving physiological and molecular adaptations in livestock …

[HTML][HTML] Gut microbiota in neurological diseases: melatonin plays an important regulatory role

S Ahmadi, M Taghizadieh, E Mehdizadehfar… - Biomedicine & …, 2024 - Elsevier
Melatonin is a highly conserved molecule produced in the human pineal gland as a
hormone. It is known for its essential biological effects, such as antioxidant activity, circadian …

Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson's disease

H Zhou, B Shen, Z Huang, S Zhu, W Yang, F Xie… - npj Parkinson's …, 2023 - nature.com
Retinal thickness is related to Parkinson's disease (PD), but its association with the severity
of PD is still unclear. We conducted a Mendelian randomized (MR) study to explore the …

Melatonin ameliorates atherosclerosis by suppressing S100a9-mediated vascular inflammation

L Chen, X Wang, C Liu, P Deng, L Pan, L Yang… - European Journal of …, 2023 - Elsevier
Atherosclerosis (AS)-associated cardiovascular diseases are predominant causes of
morbidity and mortality worldwide. Melatonin, a circadian hormone with anti-inflammatory …

[HTML][HTML] Loss of keratin 23 enhances growth inhibitory effect of melatonin in gastric cancer

L Li, M Lin, J Luo, H Sun… - Molecular …, 2024 - build.spandidos-publications.com
To investigate the effect of keratin 23 (KRT23) on the anticancer activity of melatonin (MLT)
against gastric cancer (GC) cells, microarray analysis was applied to screen differentially …

Pregnancy in Patients with Inflammatory Bowel Diseases—A Literature Review

RR Grigorescu, IA Husar-Sburlan, G Rosulescu… - Life, 2023 - mdpi.com
In recent years, we have faced an increasing incidence of inflammatory bowel disease (IBD),
especially among young people, affecting them during their reproductive years. The paucity …