Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …

Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …

Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in
evolution and characterized by a cyclic multimeric structure. C-reactive protein (CRP) and …

Age related macular degeneration (AMD) is a complex multifactorial disease caused by the
interplay of age and genetic and environmental risk factors. A common feature observed in …

Variants of the CFH gene, encoding complement factor H (CFH), show strong association
with age-related macular degeneration (AMD), a major cause of blindness. Here, we used …

The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its
potential role in inflammation. However, most pieces of evidence are sparse and …

Recognition and removal of apoptotic and necrotic cells must be efficient and highly
controlled to avoid excessive inflammation and autoimmune responses to self. The …

Myeloid-derived suppressor cells (MDSC) are immature myeloid cells that accumulate in the
circulation and the tumor microenvironment of most cancer patients. There, MDSC suppress …

The complement system is a powerful tool of the innate immune system to eradicate
pathogens. Both in vitro and in vivo evidence indicates that therapeutic anti-tumor …