Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the
world's population. The etiology of RA remains unknown. It is considered to occur in the …

Male infertility is a complex condition with a strong genetic and epigenetic background. This
review discusses the importance of genetic and epigenetic factors in the pathophysiology of …

The XIST gene is implicated in X chromosome inactivation, yet the RNA contains no
apparent open reading frame. An accumulation of XIST RNA is observed near its site of …

DNA methylation can contribute to transcriptional silencing through several transcriptionally
repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and …

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by
hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is …

It has been a controversial issue as to how many DNA cytosine methyltransferase
mammalian cells have and whether de novo methylation and maintenance methylation …

This review synthesizes a subset of human epidemiologic and experimental animal studies
that suggest that early nutrition affects susceptibility to chronic diseases in adulthood. These …

ANIMAL somatic cell DNA is characterized by a bimodal pattern of methylation: tissue-
specific genes are methylated in most cell types whereas housekeeping genes have 5 …