NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …

The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …

We have read with interest the recent article by Favalli et al. published in Autoimmunity
Reviews [1]. We agree with the Authors that Corona Virus Disease 2019 (COVID-19) …

The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …

More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …

Objective. To revise the current juvenile idiopathic arthritis (JIA) International League of
Associations for Rheumatology (ILAR) classification criteria with an evidence-based …

The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …