A high level of polycystin-1 expression is detected in kidneys of all patients with autosomal
dominant polycystic kidney disease (ADPKD). Mice that overexpress polycystin-1 also …

The 14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a novel large (~ 460
kDa) protein, polycystin-1, of unknown function that is responsible for autosomal dominant …

Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased
occurrence of cardiac valve abnormalities. However, the prevalence of cardiac …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in at least
three different genes: PKD1, PKD2, and PKD3. ADPKD1 is an inherited disorder that has led …

Autosomal-dominant polycystic kidney disease, one of the most frequent human genetic
disorders, is genetically heterogeneous. Most cases result from mutations of PKD1 or PKD2 …

The excretory cell extends a tubular process, or canal, along the basolateral surface of the
epidermis to form the nematode renal epithelium. This cell can undergo normal …

Autosomal dominant polycystic kidney disease (ADPKD) is a major, inherited disorder that is
characterized by the growth of large, fluid-filled cysts from the tubules and collecting ducts of …

PKD1 is the major locus of the common genetic disorder autosomal dominant polycystic
kidney disease (ADPKD). Analysis of the predicted protein sequence of the human PKD1 …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common human
monogenic genetic disorder and is characterized by progressive bilateral renal cysts and the …

Polycystin-1 is a novel protein predicted to be a large membrane-spanning glycoprotein with
an extracellular N-terminus and an intracellular C-terminus, harboring several structural …