The most common form of autosomal dominant polycystic kidney disease (PKD) results from
mutation of the PKD1 gene on chromosome 16p13. 3. The gene encodes a 14-kb …

IEX-1 is an immediate early gene that is induced by ionizing radiation, ultraviolet radiation,
and a variety of growth factors. It plays an important role in the regulation of cellular growth …

Discussion Colonic diverticular disease is often considered to be an extrarenal
manifestation of ADPKD. Schef et al.[1] found diverticulosis on barium enema studies in 10 …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of
epithelial cells and the influx of cyst fluid. The 14-kb mRNA of the polycystic kidney disease …

Background Hypertension is a common and serious complication of autosomal dominant
polycystic kidney disease (ADPKD), often occurring early in the disease before the renal …

Skin cancer is the most common human malignancy and is strongly associated with
exposure to ultraviolet radiation (UVR). Several mechanisms including an increase in …

Autosomal-dominant polycystic kidney disease (ADPKD) is one of the most common
monogenetic diseases in humans. The discovery that mutations in the PKD1 and PKD2 …

PKD1, the major gene mutated in autosomal dominant polycystic kidney disease, was
identified in 1994, and fully sequenced in 1995. The protein which it encodes, polycystin-1 …

The majority of different cell types in the human body have a cilium, a thin rod-like structure
of uniquely arranged microtubules that are encapsulated by the surface plasma membrane …

Colorectal cancer (CRC) is one of the leading causes of death in the civilized world.
Transient receptor potential channels (TRPs) are a heterogeneous family of cation channels …